Forschungsgruppe Neurobiochemie

Forschungsschwerpunkte

• Molekulare und zelluläre Neuropsychopharmakologie
• Neuronale/gliale Zellmodelle auf MultiElectrodeArray-Chips
• Psychoendokrinologie und -immunologie
• Molekulargenetische Untersuchungen von Kandidatengenen bei psychiatrischen Erkrankungen
• Plasmaspiegelanalytik von Psychopharmaka und Neurotransmittern

Aktuelle Projekte

• Genetische Varianten der Östrogenrezeptoren und Östrogen-metabolisierender Enzyme bei neurogenerativen Erkrankungen.
• Gen-Umwelt-Interaktionen im Rahmen der SALIA-Kohortenstudie
• Hämatologische Effekte von Neuroleptika, insbesondere von Clozapin, als Ursache der Neutropenie und Agranulozytose.
• Pleiotrope Wirkungen von Clozapin und Untersuchung der molekularen Grundlagen
• Untersuchung psychoendokriner Faktoren in Relation zu neuropsychologischen Funktionen bei forensisch-psychiatrischen PatientenCharakterisierung muriner neuronaler Netzwerke auf "Biochips (MEA-Technologie)" als Surrogat der ZNS-Aktivität in vivo.

Ausgewählte Publikationen

• Fehsel K. Why Is Iron Deficiency/Anemia Linked to Alzheimer's Disease and Its Comorbidities, and How Is It Prevented? Biomedicines. 2023;11:2421. doi: 10.3390/biomedicines11092421
• Fehsel K, Schwanke K, Kappel BA, Fahimi E, Meisenzahl-Lechner E, Esser C, Hemmrich K, Haarmann-Stemmann T, Kojda G, Lange-Asschenfeldt C. Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction. J Psychopharmacol. 2022; 36:191-201.
• Fehsel K, Christl J. Comorbidity of osteoporosis and Alzheimer's disease: Is `AKT `-ing on cellular glucose uptake the missing link? Ageing Res Rev. 2022;76:101592
• Bouvier ML, Fehsel K, Schmitt A, Meisenzahl-Lechner E, Gaebel W, von Wilmsdorff M. Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome. BMC Pharmacol Toxicol. 2022;23:8.
• Bouvier ML, Fehsel K, Schmitt A, Meisenzahl-Lechner E, Gaebel W, von Wilmsdorff M. Sex-dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long-term clozapine and haloperidol medication. Brain Behav. 2020:10:e01694.
• Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia. Trossbach SV, Hecher L, Schafflick D, Deenen R, Popa O, Lautwein T, Tschirner S, Köhrer K, Fehsel K, Papazova I, Malchow B, Hasan A, Winterer G, Schmitt A, Meyer Zu Hörste G, Falkai P, Korth C. Transl Psychiatry. 2019 May 31;9(1):156. doi: 10.1038/s41398-019-0486-6.
• First-episode psychosis and abnormal glycaemic control. Fehsel K, Löffler S.
  Lancet Psychiatry. 2017 Jan;4(1):23-24. doi: 10.1016/S2215-0366(16)30374-1.
• Genetic susceptibility for air pollution-induced airway inflammation in the SALIA study.
  Hüls A, Krämer U, Herder C, Fehsel K, Luckhaus C, Stolz S, Vierkötter A, Schikowski T. Environ Res. 2017 Jan;152:43-50. doi: 10.1016/j.envres.2016.09.028. Epub 2016 Oct 12.
• Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences. Fehsel K, Schikowski T, Jänner M, Hüls A, Voussoughi M, Schulte T, Vierkötter A, Teichert T, Herder C, Sugiri D, Krämer U, Luckhaus C. J Neural Transm (Vienna). 2016 Dec;123(12):1369-1379. doi: 10.1007/s00702-016-1620-8. Epub 2016 Sep 14.
• Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women. Schikowski T, Vossoughi M, Vierkötter A, Schulte T, Teichert T, Sugiri D, Fehsel K, Tzivian L, Bae IS, Ranft U, Hoffmann B, Probst-Hensch N, Herder C, Krämer U, Luckhaus C. Environ Res. 2015 Oct;142:10-6. doi: 10.1016/j.envres.2015.06.009. Epub 2015 Jun 16.
• Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine. Trossbach SV, Fehsel K, Henning U, Winterer G, Luckhaus C, Schäble S, Silva MA, Korth C. Behav Brain Res. 2014 Dec 15;275:176-82. doi: 10.1016/j.bbr.2014.08.064. Epub 2014 Sep 8.
• Vossoughi M, Schikowski T, Vierkötter A, Sugiri D, Hoffmann B, Teichert T, Herder C, Schulte T, Luckhaus C, Raulf-Heimsoth M, Casjens S, Brüning T, Krämer U. Air pollution and subclinical airway inflammation in the SALIA cohort study. Immun Ageing. 2014;11:5.
• Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Krämer U. Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. PLoS One. 2013;8:e83042
• Görtz P, Siebler M, Ihl R, Henning U, Luckhaus C, Supprian T, Lange-Asschenfeldt C. Multielectrode array analysis of cerebrospinal fluid in Alzheimer's disease versus mild cognitive impairment: a potential diagnostic and treatment biomarker. Biochem Biophys Res Commun. 2013;434:293-7.
• Löffler S, Körber J, Nubbemeyer U, Fehsel K. Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition". Science. 2012; 337:646.
• Luckhaus C, Henning U, Ferrea S, Musso F, Mobascher A, Winterer G. Nicotinic acetylcholine receptor expression on B-lymphoblasts of healthy versus schizophrenic subjects stratified for smoking: [3H]-nicotine binding is decreased in schizophrenia and correlates with negative symptoms. J Neural Transm. 2012;119:587-95
• Hemmrich K, Kappel BA, Paul NE, Goy D, Luckhaus C, Pallua N, Fehsel K. Antipsychotic drugs increase adipose stem cell differentiation--implications for treatment with antipsychotic drugs. J Clin Psychopharmacol. 2011;31:663-5.
• Löffler S, Klimke A, Kronenwett R, Kobbe G, Haas R, Fehsel K. Clozapine mobilizes CD34+ hematopoietic stem and progenitor cells and increases plasma concentration of interleukin 6 in patients with schizophrenia. J Clin Psychopharmacol. 2010;30:591-5.
• Löffler S, Löffler-Ensgraber M, Fehsel K, Klimke A. Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients. Int Clin Psychopharmacol. 2010;25:101-6.
• Ferrea S, Fehsel K, Cordes J, Luckhaus C. Circadian rhythm of neutrophil counts and granulocyte macrophage-colony stimulating factor (GM-CSF) under clozapine treatment: a case report. World J Biol Psychiatry. 2010;11:511-3.
• Luckhaus C, Mahabadi B, Grass-Kapanke B, Jänner M, Willenberg H, Jäger M, Supprian T, Fehsel K. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer's disease. J Neural Transm. 2009;116:905-11.
• Gummersbach C, Hemmrich K, Kröncke KD, Suschek CV, Fehsel K, Pallua N. New aspects of adipogenesis: radicals and oxidative stress. Differentiation. 2009;77:115-20. Review
• Hemmrich K, Gummersbach C, Pallua N, Luckhaus C, Fehsel K. Clozapine enhances differentiation of adipocyte progenitor cells. Mol Psychiatry. 2006 ;11:980-1
• Henning U, Krieger K, Loeffler S, Rivas F, Orozco, de Castro M, Rietschel M,. Noethen M, Klimke A. Increased levels of glucocorticoid receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders. Psychoneuroendocrinology. 2005;30: 325-332
• Fehsel K, Loeffler S, Krieger K, Henning U, Agelink M, Kolb-Bachofen V, Klimke A.:Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J. Clin. Psychopharmacol. 2005; 25: 419-426
• Schmitt A, Bertsch Th, Tost H, Bergmann A, Henning U, Klimke A, Falkai P. Increased serum interleukin-1ß and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication. Neuropsychiatric Desease and Treatment. 2005;1:171-177
• Krieger K, Klimke A, Henning U (2004): Antipsychotic drugs influence transport of the beta-adrenergic antagonist [3H]-dihydroalprenolol into neuronal and blood cells. World J Biol Psychiatry. 3004;5:100-6.
• Loeffler S, Fehsel K, Krieger K, Henning U, Klimke A. Inhibition of p38-mitogen-activated protein kinase may protect from clozapine-induced agranulocytosis. World J Biol Psychiatry. 2004;5:54-5.
• Loeffler S, Fehsel K, Henning U, Fischer J, Agelink M, Kolb-Bachofen V, Klimke A Increased Apoptosis of Neutrophils in a Case of Clozapine-induced Agranulocytosis - A Case Report. Pharmacopsychiatry. 2003;36:37-41.
• Oades RD, Klimke A, Henning U, Rao ML. Relations of clinical features, subgroups and medication to serum monoamines in schizophrenia. Hum Psychopharmacol. 2002 ;17:15-27.
• Henning U, Loeffler S, Krieger K, Klimke A Uptake of clozapine into HL-60 promyelocytic leukaemia cells. Pharmacopsychiatry. 2002;35:90-5.
• Klimke A, Löffler S, Fehsel K, Henning U. Neue Forschungsergebnisse zur Clozapin-induzierten Agranulozytose. Naber D, Müller-Spahn (Hrsg.) Clozapin – Pharmakologie und Klinik eines atypischen Neuroleptikums. Springer-Verlag, Berlin Heidelberg New York,2001; S. 21-29