Forschungsgruppe Neuroimmunologie

Forschungsschwerpunkte

Neuroimmunologische Untersuchungen bei psychischen Störungen und ihre Rolle bei der Entstehung gestörter Netzwerktopologien des Gehirns bei psychischen Erkrankungen.

Aktuelle Projekte

Konzeptionierung eines Forschungsprogramms zur Integration neuroimmunologischer und neurophysiologischer Faktoren in der Ätiopathogenese psychotischer Störungen.

Ausgewählte Publikationen

• Gaebel W, Zielasek J, Cleveland HR. Psychotic disorder in ICD-11. Asian J Psychiatr. 2013 Jun;6(3):263-5
• Gaebel W, Zielasek J. Integrative etiopathogenetic models of psychotic disorder: methods, evidende and concepts. Schizophr Bull. 2011 Sep;37 Suppl 2:S5-12
• Seitz RJ, Gaebel W, Zielasek J. Modular networks involving the medial frontal cortex: towards the development of neuropsychiatry. World J Biol Psychiatry. 2011 Jun;12(4):249-59.
• Zielasek J, Gaebel W. Modern modularity and the road towards a modular psychiatry. Eur Arch Psychiatry Clin Neurosci. 2008 Nov;258 Suppl 5:60-5.
• Kahl KG, Schmidt HH, Jung S, Sherman P, Toyka KV, Zielasek J. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett. 2004 Mar 18;358(1):58-62.
• Kahl KG, Zielasek J, Uttenthal LO, Rodrigo J, Toyka KV, Schmidt HH. Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. J Neurosci Res. 2003 Jul 15;73(2):198-205.
• Zielasek J, Bender G, Schlesinger S, Friedl P, Kenn W, Allolio B, Lauer M. A woman who gained weight and became schizophrenic. Lancet. 2002 Nov 2;360(9343):1392.
• Schmid CD, Stienekemeier M, Oehen S, Bootz F, Zielasek J, Gold R, Toyka KV, Schachner M, Martini R. Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance. J Neurosci. 2000 Jan 15;20(2):729-35.
• Mix E, Zettl UK, Zielasek J, Hartung HP, Gold R. Apoptosis induction by macrophage-derived reactive oxygen species in myelin-specific T cells requires cell-cell contact. J Neuroimmunol. 1999 Mar 1;95(1-2):152-6.
• Zettl UK, Mix E, Zielasek J, Stangel M, Hartung HP, Gold R. Apoptosis of myelin-reactive T cells induced by reactive oxygen and nitrogen intermediates in vitro. Cell Immunol. 1997 May 25;178(1):1-8.
• Zielasek J, Muller B, Hartung HP. Inhibition of cytokine-inducible nitric oxide synthase in rat microglia and murine macrophages by methyl-2,5-dihydroxycinnamate. Neurochem Int. 1996 Jul;29(1):83-7.
• Gold R, Zielasek J, Kiefer R, Toyka KV, Hartung HP. Secretion of nitrite by Schwann cells and its effect on T-cell activation in vitro. Cell Immunol. 1996 Feb 25;168(1):69-77.
• Zielasek J, Hartung HP. Molecular mechanisms of microglial activation. Adv Neuroimmunol. 1996;6(2):191-22. Review.
• Stangel M, Zettl UK, Mix E, Zielasek J, Toyka KV, Hartung HP, Gold R. H2O2 and nitric oxide-mediated oxidative stress induce apoptosis in rat skeletal muscle myoblasts. J Neuropathol Exp Neurol. 1996 Jan;55(1):36-43.
• Martini R, Zielasek J, Toyka KV, Giese KP, Schachner M. Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.Nat Genet. 1995 Nov;11(3):281-6.
• Adlkofer K, Martini R, Aguzzi A, Zielasek J, Toyka KV, Suter U. Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice.Nat Genet. 1995 Nov;11(3):274-80.
• Zielasek J, Jung S, Gold R, Liew FY, Toyka KV, Hartung HP. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J Neuroimmunol. 1995 Apr;58(1):81-8.
• Zielasek J, Reichmann H, Kunzig H, Jung S, Hartung HP, Toyka KV. Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat. Neurosci Lett. 1995 Jan 23;184(2):129-32.
• Jung S, Huitinga I, Schmidt B, Zielasek J, Dijkstra CD, Toyka KV, Hartung HP. Selective elimination of macrophages by dichlormethylene diphosphonate-containing liposomes suppresses experimental autoimmune neuritis. J Neurol Sci. 1993 Nov;119(2):195-202.
• Zielasek J, Archelos JJ, Toyka KV, Hartung HP. Expression of intercellular adhesion molecule-1 on rat microglial cells. Neurosci Lett. 1993 Apr 30;153(2):136-9.
• Zielasek J, Tausch M, Toyka KV, Hartung HP. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell Immunol. 1992 Apr 15;141(1):111-20.